Prurigo nodularis - 結節性痒疹
relevance score : -100.0%
ReferencesPrurigo nodularis は、複数の硬い隆起や小結節を特徴とする長期にわたる皮膚疾患で、主に腕や脚の外側に見られます。これらの隆起の色は肌色からピンク色までさまざまで、強いかゆみを伴います。あらゆる年齢層の人に影響を与える可能性があり、アトピー性皮膚炎など、慢性的なかゆみを引き起こす他の皮膚疾患と関連していることがよくあります。治療の選択肢には、強力な抗かゆみ薬、免疫系に作用する薬、神経系を標的とした薬などがあります。結節性痒疹の管理には、通常、長期にわたる治療が必要です。
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
治療は通常、患部にクリームやステロイド注射を用います。より重篤な場合や頑固な場合には、光療法や免疫系を抑制する薬物療法が必要になることがあります。サリドマイドとレナリドマイドは重症例の選択肢ですが、重篤な副作用が起こる可能性があります。新しい治療法 (opioid receptor antagonists, neurokinin-1 receptor antagonists) は、サリドマイドやレナリドマイドと比較して副作用が少なく、結節性痒疹の治療に有望であることが示されています。
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo は、6 週間以上続く長期のかゆみ（かゆみ）、引っかき傷に伴う皮膚病変、そして頻繁な引っ掻き歴を特徴とする皮膚疾患です。皮膚の神経炎症と線維症が関与しています。
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis（結節性痒疹）は、かゆみを伴う結節を特徴とする長期にわたる皮膚疾患です。正確な原因は不明ですが、免疫系と神経系の異常がかゆみと掻きむしりのサイクルに関与していると考えられています。現時点では、Prurigo nodularis（結節性痒疹）に特化した治療法は、米国FDAによって承認されていません。
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ 治療 ― OTC医薬品
石鹸で患部を洗っても効果がなく、むしろ悪化することがあります。OTCステロイド軟膏は症状の軽減に役立つ場合がありますが、通常、改善するには数週間の塗布が必要です。抗ヒスタミン薬を継続して服用すると、かゆみが軽減します。
#OTC steroid ointment
#OTC antihistamine
○ 処理
#Intralesional triamcinolone injection